What concerns patients with diabetes most has never been just blood sugar levels. As the leading cause of blindness among adults, diabetic retinopathy causes vision damage that is almost irreversible once it reaches th
When discussing male reproductive aging, people typically focus on three metrics: testosterone levels, sperm concentration, and DNA fragmentation rate. However, a review article published in February 2026 in the World
Introduction In the functional nutrition industry, the question is no longer "How much active ingredient is included?" but rather "How much can the body actually utilize?" For a highly fragile
Friends working in the NAD⁺ and brain health industries have likely asked themselves the same question: NR (Nicotinamide Riboside) is widely recognized as one of the most effective NAD⁺ precursors. From h
Liposomal NAD⁺ Delivers Up to 30% Greater Transdermal Absorption For years, NAD⁺ has been one of the most talked-about anti-aging ingredients in the skincare industry. Countless brands have invested heavily in developin
In de afgelopen jaren is NAD+ ongetwijfeld uitgegroeid tot een van de heetste moleculen op het gebied van anti-veroudering en gezonde levensduur. Van wetenschappelijke laboratoria tot consumentenmarkten, de discussies hierover zijn nooit gestaakt.
Aging is being redefined. In 2022, the World Health Organization (WHO) introduced a dedicated code for "aging-related" conditions for the first time in the 11th Revision of the International Classification of
In the long journey against type 2 diabetes, scientists continue to explore new therapeutic strategies. Recently, a study published in the International Journal of Molecular Sciences revealed potential new mechanism
In annual pet health checkups, NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a sensitive marker of myocardial stress. When its levels exceed the normal range, it usually indicates that the heart is under
When it comes to anti-aging, boosting energy, and maintaining vascular health, many people have heard of a specific term—NMN (Nicotinamide Mononucleotide). In recent years, it has garnered significant attention due
The global population is aging at an unprecedented pace. The World Health Organization (WHO) predicts that by 2050, the global population aged 60 and older will exceed 2.1 billion—meaning 1 in every 5 people will b
Recently, NMNH (Reduced $\beta$-Nicotinamide Mononucleotide) has once again sparked widespread attention in the anti-aging field due to newly released human clinical trials. Although both are precursor molecules of
In het vooraanstaande veld van anti-verouderingsonderzoek is de "co-enzymfamilie" een hot topic geworden binnen de industrie. NMN, een voorloper van NAD+, veroverde ooit de wereld dankzij de aanbevelingen van de prominente fi
Long COVID lingers like a persistent shadow, leaving hundreds of millions worldwide struggling with brain fog, fatigue, and insomnia. In November 2025, a team from Harvard Medical School published a 24-week double-blind
In het snelle moderne leven lijken vermoeidheid en slapeloosheid voor veel mensen "vaste gasten" te zijn geworden. Wetenschappers hebben ontdekt dat deze problemen in verband worden gebracht met de uitputting van een "ene"
De essentie van veroudering is een cellulaire "energiecrisis." Naarmate wetenschappers dieper duiken in het onderzoek naar NAD+, is dit co-enzym geleidelijk een kerndoel geworden binnen het anti-verouderingsveld. Studies hebben aangetoond dat de directeur
Energieverlies, kortademigheid bij het trappen, postprandiale bloedsuikerfluctuaties en steeds moeilijker vinden om vet te verliezen... Deze lichamelijke sensaties van "ouder worden" zijn eigenlijk de drijfveer
In April 2026, China officially released its first national consensus document: the Chinese Expert Consensus on the Role and Clinical Application of NAD⁺ in Aging-Related Diseases (2026 Edition). Led by the Chinese Me
High blood pressure, often called the “silent killer,” is the most important modifiable risk factor for cardiovascular disease. Yet many people face the same frustration: even when taking antihypertensive med
Met de veroudering van de wereldbevolking hebben degeneratieve veranderingen in het bewegingsapparaat (zoals artrose, osteoporose en sarcopenie) een ernstige invloed op de levenskwaliteit van ouderen. Wiebelige benen tijdens het lopen, di
When discussing liver health, one fundamental question arises: how can we effectively support this “biochemical factory of the human body” in its complex repair Proceses when faced with metabolic stress, fat
In the field of anti-aging, NMN (nicotinamide mononucleotide) has long been a highly regarded “star molecule.” As a direct precursor of NAD⁺, it shows great potential in energy metabolism, DNA repair, and ant
In recent years, NAD+ (nicotinamide adenine dinucleotide) has become a highly sought-after “star molecule” in the health and anti-aging field due to its tremendous potential. The most common supplements on th
For a long time, NAD (nicotinamide adenine dinucleotide) has been almost a “standard configuration” in IVD testing. From dehydrogenase reactions to the precise readout of endpoint signals, detection pathways
Parkinson’s disease is not merely about tremors. More concerning is that most patients gradually develop cognitive impairment, which may eventually progress to dementia. Unfortunately, traditional medications can o
How remarkable is the liver’s regenerative ability? Even when two-thirds of a healthy liver is surgically removed, it can restore its original size within just a few weeks. However, under conditions such as disease
In de afgelopen jaren is NAD+ vaak centraal gestaan bij populaire onderwerpen zoals gezondheid, anti-veroudering en cognitieve verbetering. Het lijkt erop dat het uit het laboratorium in het dagelijks leven is gesprongen en een nieuwe favoriet is geworden
In the vast world of raw materials, some names seem to rise to prominence overnight. Yet in reality, their success is never accidental. NRHM (Nicotinamide Riboside Hydrogen Malate) is one such name—frequently appe
Kan een enkel molecuul in het menselijk lichaam een belangrijke factor worden voor de gezondheid van het hart? Nicotinamide adenine-dinucleotide (NAD+) wordt snel een belangrijk aandachtspunt van wetenschappelijk onderzoek. Als kernspeler in energiemetabolisme
In onderzoek naar anti-verouderingsmechanismen heeft nicotinamide riboside (NR), een voorloper van NAD⁺, geleidelijk toenemende aandacht gekregen van wetenschappelijke instellingen. In september 2023 werd een nationaal uitvindingspatent ingediend met betrekking tot
Als we het over gezondheid hebben, staat de darm vaak centraal in de discussie. Het is niet alleen verantwoordelijk voor de spijsvertering en opname van voedingsstoffen, maar vertegenwoordigt ook het grootste immuunorgaan in het menselijk lichaam. In recente jaren wel
In the fields of anti-aging, cellular energy, and biotechnology, the term “NAD⁺” has almost been elevated to a mythical status. Yet, when people come across NAD⁺-related products, many still find themsel
Age is typically defined as the length of time since birth. However, a person’s true physical condition and degree of aging are better reflected by their biological age rather than the number of years they have liv
Naarmate de bewustwording van gezond eten blijft toenemen, zijn calorievrije natuurlijke zoetstoffen een belangrijk aandachtspunt van consumenten geworden. In juni 2025 werd een studie gepubliceerd in het internationale tijdschrift Food Chemistry: X systematic
While we are deeply engaged in exploring anti-aging solutions for humans, our furry companions at home are quietly facing health challenges brought on by aging—reduced energy levels, dull coats, and a slower metabo
Have you ever experienced moments like these: walking into a room and forgetting why you went there, struggling to recall a familiar name, or suffering from persistent insomnia after staying up late—followed by day
In today’s global wave of health awareness, “sugar reduction” has become a widely accepted trend. Steviol glycosides, as natural zero-calorie sweeteners, have already entered households worldwide. Howev
Recently, a study published on bioRxiv revealed the metabolic secrets behind the remarkable longevity of centenarians. Led by Boston University, the research conducted metabolomic analyses on 213 participants—
In de moderne zoektocht naar gezondheid en een lang leven is de wetenschappelijke focus verschoven van macronutriënten naar het cellulaire energiemetabolisme. Onder de vele opkomende moleculen is Nicotinamide Riboside (NR) uitgegroeid tot een rijzende ster in de levenswetenschappen
Naarmate de wereldbevolking ouder wordt, is het aanpakken van leeftijdsgebonden cognitieve achteruitgang en fysieke achteruitgang een grote wetenschappelijke uitdaging geworden. In april 2025 werd een baanbrekende studie gepubliceerd in Frontiers in Phar
Introduction: As time quietly passes, have you noticed your once lively dog becoming slower to respond or experiencing disrupted sleep? Don’t worry — science is bringing new hope! The latest clinical trial h
Global population aging is becoming increasingly pronounced. It is estimated that by 2050, the number of people aged 65 and above will reach 1.6 billion—double the 780 million recorded in 2020. As aging progresses,
Een gloednieuwe gezaghebbende studie is hier! Een experiment uit 2025 door het team van Northwest A&F University, gepubliceerd in het Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), onthulde met strenge data
September 29, 2025 — After nearly three years of pressure from the Natural Products Association (NPA), the U.S. Food and Drug Administration (FDA) has reversed course and confirmed that Beta (β) Nicotinamide M
In recent years, “N-series” anti-aging dietary supplements represented by NMN and NR have continued to gain popularity in markets across Europe, the U.S., Japan, and China. The core mechanism of these product
In the world of nutrition, some substances have existed for over a hundred years but have only recently been recognized for their great value. Ergothioneine (EGT) is such a modest yet precious dietary component. △ Ch
Volgens het nieuwste onderzoek dat is gepubliceerd in gezaghebbende tijdschriften zoals *Nature Metabolism*, tonen menselijke metabolomics-gegevens niet-lineaire dramatische veranderingen tussen de leeftijd van 30 en 50 jaar. Deze omvatten lipidmetabolisme IMB
Do you often feel exhausted? Struggled with blood sugar issues for years? Or perhaps you’re seeking anti-aging solutions and vibrant health? Today, let’s explore a powerful “energy key” hidden dee
NAD+: The Indispensable 'Cell Fuel' and 'Repairman' NAD+ is a key coenzyme involved in cellular energy metabolism (e.g., converting food into ATP), DNA repair (e.g., activating PARP enzymes), and regulat
In an age where the pursuit of 'frozen age' and 'reverse growth' is on the rise, anti-aging is no longer a distant dream. The core molecule—NAD+ (Nicotinamide Adenine Dinucleotide)—plays a cri
Naarmate de publieke interesse in gezond ouder worden en een lang leven blijft groeien, heeft het onderzoek naar de NAD⁺ (Nicotinamide Adenine Dinucleotide) metabolisme aanzienlijk aan kracht gewonnen. NMNH (Reduced Nicotinamide Mononucleotide), de redu
Ginseng, een legendarisch kruid in de traditionele geneeskunde, wordt al millennia gebruikt vanwege de talloze gezondheidsvoordeel. Centraal in zijn medicinale kracht staan ginsenosiden, krachtige saponinen die de interesse van de mod hebben gewekt
Ginseng, eeuwenlang vereerd in de traditionele Chinese geneeskunde, staat bekend om zijn opmerkelijke therapeutische eigenschappen. Centraal voor de effectiviteit zijn ginsenosiden, een diverse groep saponinen die als de actieve s worden beschouwd
Nicotinamide Adenine Dinucleotide Phosphate (NADP), a crucial coenzyme in cellular metabolism, serves as a cornerstone in numerous biochemical reactions. As a derivative of NAD, it adds a phosphate group which enhan
De wereld van de biochemie zit vol met moleculen die, hoewel niet altijd in de schijnwerpers, een cruciale rol spelen in het onderhoud en de regulatie van cellulaire Procesen. Onder deze vallen geoxideerde co-enzymen eruit
In de ingewikkelde wereld van de biochemie spelen co-enzymen een cruciale rol bij het faciliteren van talrijke metabole reacties die essentieel zijn voor het leven. Een van deze cruciale co-enzymen is Nicotinamide Adenine Dinucleotide Fosfaat (NADP). Dit
In de wereld van natuurlijke zoetstoffen heeft stevia een belangrijke plek veroverd dankzij de uitzonderlijke zoetheid en gezondheidsvoordeel. Afkomstig van de bladeren van de Stevia rebaudiana-plant, deze calorievrije zoetstof h
In the world of dietary substances, every detail matters—from the source of the ingredients to the color of the final product. For those curious about the health benefits of Nicotinamide Mononucleotide Hydrogen (NM
In het veranderende landschap van gezondheids- en wellnessstoffen is de zoektocht naar effectievere oplossingen om veroudering tegen te gaan en de cellulaire gezondheid te verbeteren voortdurend aanwezig. Een van de belangrijkste ontwikkelingen van deze ontwikkelingen is het gebruik van NAD+ enh
In the expansive world of biochemical research and health preservation, certain compounds emerge as particularly significant due to their potential applications and benefits. One such compound is NMNH, which sta
Nicotinamide adenine dinucleotide hydrogen (NADH) is a lesser-known yet crucial molecule in the biological sciences and various health-related fields. In this blog, we explore the wide-ranging applications of NA
In de zoektocht naar het behouden van jeugdige energie en gezondheid naarmate we ouder worden, blijft wetenschappelijk onderzoek nieuwe stoffen naar voren brengen die deze zoektocht kunnen ondersteunen. Een van de meest veelbelovende hiervan is Beta-Nicotinamide Mononu
In the quest for optimal health and vitality, understanding the role of coenzymes in cellular function is paramount. Nicotinamide Adenine Dinucleotide Hydrogen (NADH) is one such coenzyme that plays a critical r
Nicotinamide adenine-dinucleotide (NAD+) is een hoeksteen van de cellulaire gezondheid en speelt een cruciale rol in de energieproductie en metabole Procesen die het leven in stand houden. Naarmate we ouder worden, nemen de niveaus van NAD+ natuurlijk af, leadin,
Energy metabolism is a crucial biological Proces that involves converting food into the energy needed to power all cellular activities. It is fundamental to maintaining health, vitality, and overall well-being. One
Op het gebied van gezondheid en welzijn is het behouden van optimale cellulaire functie essentieel voor algehele vitaliteit en een lange levensduur. Een molecuul dat centraal staat in tal van biologische Procesen is Nicotinamide Adenine-dinucleotide
In de zoektocht naar vitaliteit en een lang leven hebben de wetenschappelijke doorbraken rond Nicotinamide Mononucleotide (NMN) de aandacht getrokken van gezondheidsliefhebbers wereldwijd. BONTAC, een leider in biochemische innovatie
In de zoektocht naar gezondheid en een lang leven leiden wetenschappelijke doorbraken ons vaak naar natuurlijke stoffen die ons welzijn aanzienlijk kunnen verbeteren. Een van die stoffen heeft de aandacht getrokken van de gezondheids- en welzijnsafdeling
In de snel evoluerende biotechnologiesector hervormen producten afkomstig van biologische Procesen en organismen industrieën van gezondheidszorg naar landbouw. De biotechnologiemarkt is fel concurrerend, wi
In de dynamische wereld van gezondheid en biotechnologie springt cellulaire verjonging eruit als een revolutionair concept, dat een nieuw tijdperk van verbeterde gezondheid, langere jeugd en een betere levenskwaliteit belooft. Als leider in de glo
In the rapidly evolving landscape of health and wellness, metabolism-boosting products have emerged as key components in enhancing human health, optimizing metabolic Proceses, and supporting various bodily functi
Introduction In the realm of animal husbandry, feed additives are necessary as they can not only improve the nutritional value of feed and optimize the internal environment of the rumen, but also enhance
Introduction Nicotinamide adenine dinucleotide (NAD) deficiency has been linked to a range of renal disorders, encompassing conditions such as acute kidney injury, diabetic nephropathy, adenine-triggered kidney diseas
Introduction In response to the escalating global obesity rates, the demand for sugar reduction has reached a critical juncture. As a strategic pivot, the food industry has increasingly incorporated sugar substitutes,
Introduction Parkinson's disease (PD), known as the silent killer, has emerged as the second most common chronic neurodegenerative disease in the world after Alzheimer's disease, affecting
Introduction Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme in cells, a central cofactor of redox reaction and a central regulator of various metabolisms in the human body. It is involved in a
Introduction Spinal cord injury (SCI) can lead to severe impairments in motor, sensory, and autonomic nervous system functions. It has been reported that motor function recovery can be promoted by mediatin
Introduction Chronic cerebral hypoperfusion (CCH) has been identified as one of the initial conditions critical to the development of cognitive impairment, which is tightly associated to the complex neurologic
Introduction Stroke remains the second leading cause of death and the third leading cause of death and disability combined in the world, as reported in 2019 Global Burden of Disease Study. Ischemic stroke
Introduction Myocardial ischemia/reperfusion (MI/R) can damage the heart muscle, which may contribute to further cardiomyocyte death. Following percutaneous coronary intervention therapy, patients with MI/
Introduction According to the report by World Health Organization (WHO) in 2017, depression is the third leading cause of the global disease burden, with over 300 million people suffering from this disease w
Thanks to our unrelenting dedication to creating cutting-edge solutions that push the frontiers of scientific development, BONTAC has long been at the forefront of the biochemical sector. We are excited to present o
Our unshakable dedication to maximizing the potential of traditional Chinese medicine has propelled BONTAC to the forefront of the natural products sector for a considerable amount of time. We are thrilled to presen
Our unwavering quest of innovation at BONTAC has always been sparked by our profound grasp of the natural world and its unrealized potential. We are excited to present our ground-breaking solutions today, which are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries and improve lives, we at BONTAC have long been at the forefront of the green biotechnology revolution. We are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries and improve lives, BONTAC has long been at the forefront of the green biotechnology revolution. We are ex
For many years, BONTAC has been acknowledged as a leader in the field of green biotechnology, thanks to our unwavering commitment to creating ground-breaking products and services that have the potential to improve
Because of our unwavering search for products that have the power to genuinely change the lives of our partners and consumers, we at BONTAC have long been at the forefront of cutting-edge green biotechnology solutio
Being deeply aware of the vital role our products play in enabling people to live healthier, more fulfilling lives has always motivated us at BONTAC to innovate. We are pleased to announce our ground-breaking NMNH,
Propelled by an unwavering dedication to innovation and a profound comprehension of the crucial function this coenzyme plays in preserving cellular health and lifespan, BONTAC has been at the forefront of the NAD+ a
Bij BONTAC, we have always been driven by a relentless pursuit of innovation – a desire to push the boundaries of what is possible in the realm of nutritional supplements and biomedical research. Today, we are thril
Bij BONTAC zijn we al lange tijd gepassioneerd over het nastreven van geavanceerde voedingsoplossingen die de menselijke gezondheid en welzijn echt kunnen transformeren. Vandaag zijn we enthousiast om een van de meest opmerkelijke in de schijnwerpers te werpen
Bij BONTAC hebben we altijd vooroplopend gestaan in baanbrekend nutraceutisch onderzoek, toegewijd aan het ontdekken van de meest opmerkelijke en transformerende verbindingen die de natuur te bieden heeft. Vandaag zijn we verheugd om je voor te stellen
For many years, BONTAC has been at the forefront of innovative biopharmaceutical developments, committed to maximizing the life-changing potential of nature's most extraordinary substances. We are excited to pre
Bij BONTAC staan we al lange tijd voorop in innovatie op het gebied van biofarmaceutica, toegewijd aan het benutten van de kracht van baanbrekende wetenschappelijke ontdekkingen om het leven van degenen die we bedienen te verbeteren. Vandaag zijn wij een
Bij BONTAC worden we gedreven door een diepgaande toewijding om mensen te versterken met de tools die ze nodig hebben om optimale gezondheid en welzijn te bereiken. Als marktleiders op het gebied van biotechnologie hebben wij ons toegewijd
Bij BONTAC is het onze missie om mensen te voorzien van de tools die ze nodig hebben om optimale gezondheid en welzijn te bereiken. Als pionier op het gebied van biotechnologie hebben wij ons toegewijd aan het ontdekken van het diepgaande voordeel
Bij BONTAC zetten we ons diep in om de grenzen van menselijke gezondheid en welzijn te verleggen. Als toonaangevende innovator op het gebied van biotechnologie richten we ons op het benutten van het ongelooflijke potentieel van Beta-Nicoti
As a leading player in the world of biotechnology, BONTAC is at the forefront of driving innovation and transforming the industry. Our unwavering commitment to scientific excellence and our deep understanding of the
Bij BONTAC worden we gedreven door een onvermoeibare streven naar innovatie en een diepe toewijding aan het verbeteren van het leven van degenen die we bedienen. Als voorlopers op het gebied van cellulaire gezondheid en verjonging zijn we enthousiast om onze
Bij BONTAC staan we voorop in de metabolismeverhogende productindustrie, gedreven door onze onwankelbare toewijding aan innovatie en het streven naar wetenschappelijke excellentie. Onze focus op het ontwikkelen van baanbrekende oplossingen h
Introduction With changes in lifestyles and dietary structure, hyperuricemia shows an increasing prevalence year by year, which may become the second largest metabolic disease after diabetes mellitus, a
Introduction Steviol glycosides are secondary metabolites obtained by extracting and isolating stevia from the herbaceous plant Stevia rebaudiana of the Asteraceae family, with a high degree of sweetness
NAD is an abbreviation for nicotinamide adenine dinucleotide, which is a naturally occurring coenzyme (a substance that works with enzymes) found in our bodies. It helps cells produce energy. However, as we age, NAD
Introduction According to the report of International Agency for Research on Cancer (IARC), there are 19.3 million new cases of malignant tumors and 10 million deaths worldwide in 2020. Malignant tumors have overtaken
Introduction Elderly individuals are at a significantly higher risk for peripheral artery disease (PAD), a common vascular disorder. As the global population ages rapidly, the number of PAD cases is projected to rise
Introduction Diabetic kidney disease (DKD) has emerged as one of the primary cause of mortality among the patients with end-stage renal disease such as renal failure, accounting for 30-50% of chronic renal failure cas
Introduction Nicotinamide adenine dinucleotide (NAD+) metabolism is essential for maintaining normal physiological activities, and the decreased NAD+ level is related to various pathologies such as cardiac dis
Introduction Targeting the autophagy-NAD axis has been reported be a viable therapeutic strategy for Niemann-Pick type C1 (NPC1) disease. The study suggests that both pharmacological rescue of autophagy deficiency and
Introduction Apical periodontitis, an inflammatory disease affecting tooth apex tissues, is triggered by oral pathogens infecting the root canal. One of the main reason for endodontic treatment failure is Enterococcus
Introduction Amoebiasis has emerged as the third most common cause of death by parasites worldwide after malaria and schistosomiasis infections. According to the report of World Health Organization, over 40 milli
Introduction Disturbance in hepatic NAD+ metabolism has been manifested as a key factor in the initiation and progression of nonalcoholic fatty liver disease (NAFLD), one of the most co
Introduction According to the 2017 Commission on Traumatic Brain Injury (TBI), TBI remains one of the top three causes of injury-related death and disability up to 2030. There are 50~60
Introduction In clinical settings, doxorubicin (DOX) is an effective broad-spectrum anti-cancer drug in chemotherapy for various tumors, including hematological malignancies and solid tumors such as leu
Introduction Cigarettes containing nicotine (Nic) and sugar-sweetened beverages (SSBs) with high fructose corn syrup (HFCS) have been uncovered to induce hepatic steatosis, which are the risk factors for the developme
Introduction Acute promyelocytic leukemia (APL), the M3 type of acute myeloid leukemia (AML), typically relies on all-trans retinoic acid (ATRA) as its primary treatment. While APL patients treated with
Introduction Recent research unveils that hepatic insulin resistance (IR) and steatosis in obesity have a strong association with endoplasmic reticulum (ER)-mitochondria miscommunication. Notably,
Aging is an undeniable reality of life. It is a known fact that with increasing age, different body functions tend to decline. While we may not completely stop this decline, we can slow it down with pure NMN po
Introduction In the presence of oxygen, tumors produce adenosine triphosphate (ATP) through glycolysis instead of mitochondrial oxidative phosphorylation, a phenomenon known as the “Warburg effect”. Aerobi
Introduction Age-related macular degeneration (AMD) has become one of the leading cause of low vision and even blindness in the elderly, especially in those above 50. In 2020, approximately 1.8 million people aged ove
Introduction Natural products, including single components or extracts of herbal medicines, have the features of good efficacy and low toxicity when used in tumor treatment. They have unique advantages in treating dis
Introduction Reproductive dysfunction is frequent in female suffering from type 1 diabetes (T1D), up to 40% of whom will develop a variety of reproductive dysfunctions throughout their lives. T1D patients often ha
In today's health and anti-aging fields, NMN (nicotinamide mononucleotide) has attracted a lot of attention. As an important cellular coenzyme, NMN plays a key role in maintaining cell health and delaying the aging p
Introduction Ginsenoside Rg3 (Rg3) holds great promise as a potential drug for preventing scar formation, but it is often difficult for it to work alone due to its poor water solubility and low bioavail
Introduction Lead (Pb) contamination in aquatic environments poses a significant threat to the health and well-being of aquatic organisms, including fish species. There is rising popularity of prebiotics and probi
Elevating Wellness: BONTAC's NMN Powder Offerings As we delve into the realm of health and wellness, the spotlight shines brightly on NMN powder, a powerful supplement embraced by many for its potential benefits.
Innovating Solutions: BONTAC's Biotechnology Product Offerings In the ever-evolving landscape of biotechnology products, BONTAC remains a trailblazer in providing cutting-edge solutions that drive innovation
Revolutionizing Biotechnical Research: BONTAC's Trailblazing Discoveries In the dynamic realm of biotechnical research, BONTAC stands at the forefront of innovation, dedicated to driving progress and breakthr
Elevating Health with BONTAC's Cutting-Edge Longevity Supplements In the realm of health and wellness, the demand for high-quality metabolism-boosting supplements continues to rise. Bij BONTAC, we recognize the c
Introduction It has been reported that infection with Gram-negative bacteria can disrupt the osteogenic differentiation. Notably, nicotinamide mononucleotide (NMN) protects against osteogenesis from inflammat
Pioneering Discoveries: BONTAC's Innovations in Biotechnical Research In the dynamic realm of biotechnical research, BONTAC stands at the forefront of innovation, dedicated to driving progress and breakthroug
Voedend Welzijn: BONTAC als toonaangevende leverancier van grondstoffen voor supplementen As a prominent raw material supplier of supplements, BONTAC is dedicated to developing and delivering premium products that promote he
Unleash Vitality and Renewal: BONTAC's Cutting-edge Cellular Rejuvenation Solutions Cellular Rejuvenation plays a vital role in enhancing vitality and promoting overall wellness. Bij BONTAC, we are dedicated t
Introduction Hepatocellular carcinoma (HCC) is hypervascular solid tumor with rapid deterioration, poor overall prognosis and a high recurrence rate, accounting for 90% of primary liver cancers, which ha
Gezondheid verhogen: BONTAC Advanced Grondstoffen voor Cellulaire Gezondheidssupplementen In today's fast-paced world, the quest for optimal health and wellness has led to a surge in the demand for high-quality cellular
Powering Health and Vitality: BONTAC's Metabolism-boosting Product Portfolio In the dynamic landscape of health and wellness, the demand for cutting-edge metabolism-boosting products continues to
Unlocking the Power of Metabolism-Boosting Supplements: A Guide by BONTAC In the realm of health and wellness, the demand for high-quality metabolism-boosting supplements is steadily rising. Bij BONTAC,
Introduction Artificial insemination with chilled ram semen is commonly used method in livestock industry. But storing sperm in chilled conditions may cause changes in sperm membrane function and structure, and
Introduction In light of a statistics report by World Health Organization (WHO), there are 18 million people suffering from rheumatoid arthritis (RA) worldwide in 2019, where the prevalence of female is 2.5 times
Introduction Glaucoma is regarded as the second dominant cause of blindness across the world. With the amounting number and proportion of elderly people, it is estimated that 111.8 million people will have glaucom
Introduction Triocresyl phosphate (TOCP) is widely used in the realm of industry and agriculture in the last century. However, it is subsequently banned due to the increasing understanding of its toxicity. In
Introduction Cardiovascular diseases (CVD) poses huge economic burden and great threat to the life of patients, even surpassing Alzheimer's disease and diabetes. 17.9 million people in the world
Introduction Myocardial ischemia-reperfusion (I/R) injury has emerged as an urgent clinical issue that may offset the benefits of reperfusion therapy and even worsen the prognosis of acute myocardial infarction, a
.two-side{ text-align: justify; display: flex; justify-content: space-between; } Introduction The crucial parts of nicotinamide adenine dinucleotide (NAD+) and its metabolites in aging a
Introduction Ginsenoside Rh2 nanoliposome formulation has been proved to effectively target and deliver drugs to the tumor site, with less side effects and higher treatment efficiency, holding great promise in the
Introduction Replenishing nicotinamide mononucleotide (NMN) to raise the availability of nicotinamide adenine dinucleotide (NAD+) has been deemed as effective approach to prevent neurodegeneration in aging and pat
Introduction Rare ginsenoside Rg3, an active extract from Panax ginseng, is reported to possess a wide range of pharmacological properties including anti-angiogenesis and anti-cancer, with high lipophilicity (esti
Introduction Wound healing is a sophisticated Proces responding to tissue damage, which is associated with numbers of interaction of various cell types, cytokines, growth factors, and other molecules. Strikingly,
Introduction Diabetes is one of the dominant causes of death and disability worldwide, greatly affecting the life quality of patients. According to the latest data on diabetes released by the Lancet (GBD Study 202
Introduction Intervertebral disc degeneration (IDD) is a frequently seen orthopedic disease, which is accompanied with excessive apoptosis of nucleus pulposus cells (NPCs) and degeneration of extracellular ma
Introduction Ginsenoside Rg3 is Panaxanediol type tetracyclic triterpenoid saponin monomer extracted from the root of Panax ginseng, which has a wide range of pharmacological effects including anti-tumor, neuroprotect
Introduction The gut is a diverse and dynamic microbiotic system. There are about 100 trillion microorganisms in the gut, which is mainly composed of anaerobic, partially anaerobic, and aerobic bacteria. In the pr
Introduction Mar 4th is determined as the World Obesity Day. World Obesity Federation, UNICEF and WHO have hosted a global youth-led webinar to talk about obesity & youth. The obesity crisis has gradually attr
Introduction Nicotinamide mononucleotide (NMN), one precursor of nicotinamide adenine dinucleotide (NAD+), has been ascertained to be implicated with multiple biological Proceses such as cellular redox regulation and
Introduction Alpers' disease is both a neurodegenerative disorder and a metabolic disorder, which is tightly linked to mitochondrial dysfunction and mutations in the catalytic subunit of polymerase
Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen and an electron donor, which participates in diverse physiological Proceses such as protein synthesis, DNA repair,
Introduction Ginsenoside Rh2, one protopanaxadiol (PPD)-type rare ginsenoside in Panax ginseng, is uncovered to possibly have broad-spectrum pharmacological activity in diversified tumors. It is utili
Introduction Solute carrier family 25 member 51 (SLC25A51) is perceived as a mammalian transporter, which is capable of importing oxidized nicotinamide adenine dinucleotide (NAD+) into mitochondrial matrix. Remark
Introduction Oxidized form of nicotinamide adenine dinucleotide (NAD+) and its precursor nicotinamide mononucleotide (NMN) have been uncovered to restore DNA repair and prevent cancer progression via the deleted i
1. Introduction Disrupted nicotinamide adenine dinucleotide (NAD+) metabolism is increasingly deemed to be one of risk factor for amendable cardiovascular disorders. A substantial evidence has mirrored that res
1. Introduction Rare ginsenosides, a group of dammarane triterpenoids that exist in low natural abundance, fuels a high concern from scholars recently, showing great potential as shining components in drugs and nu
1. Introduction Nicotinamide adenine dinucleotide (NAD) has been unveiled to be essential for embryonic development. Patients with genetic variants in the NAD+ de novo synthesis pathway often have congen
1. Introduction The gut microbiota has long been regarded as one of the key elements contributing to the regulation of host health. Any changes in the composition or quality of the gut microbiota may have physiolo
1. Introduction Nicotinamide adenine dinucleotide (NAD) compartmentalized in adipocytes can modulate adipocyte differentiation and gene expression, in addition to controlling glucose metabolism. White adipose tiss
1. Introduction Nicotinamide mononucleotide (NMN) supplementation has been suggested to hamper the inflammatory responses via restoring NAD+ level and downregulating the expression of C
1. Introduction Age-related NAD+ depletion affects physiological functions and contributes to various aging-related diseases. NAD+ precursors can significantly elevate NAD+ level in murine tissues, effectivel
1. Introduction In mammalian cells, the majority of NAD+ is produced from metabolites entering the NAD+ salvage pathway. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme of the salvage
NMNH, ook bekend als nicotinamide mononucleotide hydraat, is een essentieel co-enzym dat in alle levende cellen voorkomt. Het speelt een cruciale rol in de cellulaire stofwisseling, energieproductie en diverse biosynthetische Procesen. Hoge zuiverheid N
Op het gebied van gezondheidssupplementen valt NADH op als een cruciale co-enzym die betrokken is bij de cellulaire stofwisseling. Het belang ervan voor het behouden van energieniveau en het ondersteunen van het algehele welzijn heeft het tot een gewaardeerd ingrediënt gemaakt voor
1. Introduction Nicotinamide Mononucleotide (NMN) has been deemed as a functional nutrient for improving human intestinal health. In this study, an in vitro simulated digestion model
1. Introduction Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects the motion-related nerve cells in the brain and spinal cord. The disease is featured by the d
1.Introduction A series of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, are accompanied with bioenergetic maladaptations and axonopathy wi
1. Introduction Diabetic peripheral neuropathy (DPN) is one of the most frequent complications of diabetes, ans also a major cause of foot ulcers, disability, and eventual amputation. With the prolongation of the
1.Introduction Mitochondria, a type of highly plastic organelle, can maintain a relatively stable dynamic equilibrium state towards the morphology, structure, quantity, volume, quality, and function
1. Introduction Bijherosclerosis is a chronic progressive inflammatory disease, which is featured by the accumulation of lipids in the intima of the arteries with yellow appearance. This disease
1. Introduction Mitochondria are the center of energy metabolism in cardiomyocytes, which are necessary for maintaining normal myocardial contractility and cardiac function. Typically, the de
1. Introduction According to the 2020 report of World Health Organization (WHO), there are approximately 2.3 million cases with breast cancer worldwide. Breast cancer has emerged as one of the
1.Introduction The senescence in mammals is generally concomitant with the dysregulation of intestinal homeostasis and the accumulation of mitochondrial DNA (mtDNA) mutations. High-burden mtDNA mutations lead to N
1. Introduction Bij present, vaccine is the preferred option for the prevention of foot-and-mouth disease (FMD), for which the adjuvant is essential due to its strong role in boosting immune response associated wi
1. Introduction Acute lung injury comprises a uniform response of the lung to inflammatory or chemical insults which is commonly caused by systemic illness including sepsis or trauma, infection with pathogens, and tox
1. Introduction Gastric cancer (GC) represents a global health-care challenge, which is the fifth most common cancer and the fourth leading cause of cancer death across the world in 2020, with a significant
1. Introduction Supplementation of nicotinamide mononucleotide (NMN) to upregulate the level of nicotinamide adenine dinucleotide (NAD+) has been unveiled to be a promising anti-aging intervention. However, it is
1.Introduction Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), also known as reduced coenzyme II, is a critical cofactor in cellular antioxidant systems and lipid synthesis, which links insulin
1. Introduction Dengue fever is an acute infectious disease caused by the Dengue virus through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito, with the main symptoms such as hi
1. Introduction The NAD precursor nicotinamide mononucleotide (NMN) shows a beneficial effect on ageing, yet excessive NMN accumulation may lead to axon degeneration. How to make the anti-ageing
1 Introduction Nicotinamide riboside (NR), a derivative of vitamin B3, is a new type of bioactive substance, which can be generated by binding a carbohydrate molecular ribose with nicotinamide (a
1. Introduction Heart failure is a serious condition in the development of cardiovascular disease. In particular, diastolic heart failure, as one of the most common manifestations of heart failure in
1. Introduction Ginseng has always been highly perceived as a valuable traditional Chinese medicine in China. Currently, much attention also has been paid to ginsenosides, the main active ingredients extracted from g
1. Introduction On July 2023, the World Health Organization (WHO) has classified the soda sweetener aspartame as a possible carcinogen, but said that aspartame is safe to consume with
Myocardial mitochondria are primary sites of myocardial energy metabolism. Mitochondrial disorders are associated with various cardiac diseases. Mitochondrial translation defects cause not only mitochondrial
De ontstekingsreactie en verstoring van de huidbarrière veroorzaakt door oxidatieve stress spelen een cruciale rol in het proces van atopische dermatitis (AD). Lipideperoxidatieniveaus zijn vaak hoger bij AD-patiënten, terwijl antio
Vitamine D en B3 (niacine) kunnen helpen bij de immuunactivatie en de heropbouw van CD4+ T-cellen in INR's. NAD, essentieel voor de cellulaire functie, neemt af met de leeftijd en wordt in verband gebracht met verschillende ziekten. NAD-boosters zoals NMN, NR en NAM showen het gala.
Sepsis, marked by dysregulated infection response, lacks effective treatment. NAD+'s role in inflammation remains unclear. NAD+ transport challenges limit its therapeutic impact. Novel NAD+-loaded nanoparticles (NPs)
In klinische diagnostiek zijn enzymen belangrijke biokatalysatoren en spelen ze een sleutelrol in veel biochemische reacties. Deze enzymen hebben co-enzymen nodig, wat wij Diagnostische Reagensco-enzymen noemen, om hun functies uit te voeren.
De bloed-hersenbarrière (BBB) is een cruciaal onderdeel van het centrale zenuwstelsel dat de uitwisseling van moleculen tussen de hersenen en de bloedbaan reguleert. Leeftijdsgebonden veranderingen in de BBB kunnen leiden tot een toename per
Vaatdementie is een van de ernstige en onomkeerbare syndromen van verworven intelligentiestoornissen veroorzaakt door een reeks cerebrovasculaire aandoeningen. Citicoline is de afgeleide van de nucleozijde, die niet alleen kan exhi
In the quest for a healthier lifestyle, the sweetener debate continues to rage. While sugar has long been the default choice, its adverse health effects have prompted a search for alternatives. One such swe
The nicotinamide adenine dinucleotide (NAD+ )/reduced NAD+ (NADH) and NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular redox homeostasis and for modulating numerous biologic
Hypertensie is een groot wereldwijd gezondheidsprobleem, gekoppeld aan miljoenen sterfgevallen door hart- en vaatproblemen. Het betreft endotheeldisfunctie en arteriële stijfheid, wat bijdraagt aan atherosclerotische aandoeningen. VA verbeteren
Suikerrijke diëten hebben geleid tot een toenemende prevalentie van verschillende chronische ziekten, waaronder obesitas, diabetes, hart- en vaatziekten en hoge bloeddruk, wat een aanzienlijk wereldwijd volksgezondheidsprobleem vormt. Stevia Rebaudiosid
CFS is a disorder of unknown etiology, consisting of prolonged, debilitating fatigue, and a multitude of symptoms including neurocognitive dysfunction, flu-like symptoms, myalgia, weakness, arthralgia, low-grade fev
Alcohol is een soort psychoactieve stof die al eeuwenlang in verschillende culturen wordt gebruikt. Alcoholgebruik is de belangrijkste oorzaak van acute leverschade en chronische leverziekte. Alcoholisme kan de mens versnellen
Stevia (Stevia rebaudiana Bertoni), een vaste struik uit de familie Compositae, wordt in veel regio's over de hele wereld geteeld. Het is beroemd om zijn zoetheid, wat te danken is aan de aanwezigheid van steviolglycosiden, die 1
Stevioside is een natuurlijke zoetstof die afkomstig is van de steviaplant. Het heeft een hoge zoetheidsintensiteit en een laag caloriegehalte, waardoor het aantrekkelijk is voor diabetici en anderen met koolhydraatbeheerde diëten. Stevios echter
Highlight: In chronic HBV infection elevated ROS production is associated to high DNA damage in HBV-specific CD8 T cells - Response to DNA damage is dysfunctional - Up-regulation of CD38 and persistent activatio
In the pass decades days, the Open AI and the amazing founder behind AI application both captured attention world widely. But recently, as MIT Technology Review reported, the OpenAI CEO Sam Altman has turned ou
NMNH versterkt NAD+ krachtig en onderdrukt glycolyse, de TCA-cyclus en celgroei NAD+ is essential for biological Proceses such as metabolism and DNA repair, and its decline is associated with age-related diseas
Ginsenosides on Cancer and Related Clinical Studies Cancer is a leading cause of death globally, and its treatment often involves a combination of surgery, chemotherapy, and radiation therapy. These treatm
Groeigekoppelde enzymengineering door manipulatie van redoxcofactorregeneratie An increasingly wide range of chemicals are now being produced from renewable feedstocks through biotechnological means. Biopro
Supervision Policies for NMN in Japan, China, America, Australia and Canada The mainstream researches of NMN have been conducted since a decade years ago. The United States had already carried out its commerciali
Collections of Clinical Trails on NMN Oral Administation NMN, as one of NAD+ booster family critical members, become increasingly popular on the market in the filed of health pomoting. And to date, there are
Nu het wereldwijde beleid voor epidemiebeheersing versoepelt, hebben inwoners van China, India, Maleisië, Japan en Singapore in verschillende mate te maken gehad met een tekort aan medicijnen. Maar aan de andere kant, het type medicijnen av
Bijtention! The Cambridge University Researchers Found Ursodeoxycholic Acid (UDCA) Can Prevent and Treat Covid-19 The International academic journal Nature published an article titled FXR inhibition may protect from SARS
Op 10 augustus 2021 publiceerden onderzoekers van de Shanghai University of Science and Technology een artikel getiteld NAD+ supplement versterkt tumordodende functie door defecte TUBBY-gemedieerde NAMPT-transcrip te redden
